By William E. Paul
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Additional resources for Annual Review of Immunology Volume 1 1983
44 NOSSAL HGG,the F(abl)2 fragment of HGG,or bovine serum albumin (BSA). Conjugates were prepared that possessed a meanof 2, 5, 8, or 12 FLU residues per moleculeof protein. It wasfoundthat with all conjugates tested, the newborncells were moresensitive to negative signaling than were adult cells. However,the gap betweenimmatureand maturecell, in terms of sensitivity, varied widelyfromconjugateto conjugate. For all three carriers, the higher the haptendensity, the lowerthe molarity required for tolerance induction.
This was closely analogousto earlier studies with non-covalentflagellin-antibody complexes(43). However,whenthe animalhad beenpre-primedagainst the Annual Reviews Annu. Rev. Immunol. 1:33-62. org by HINARI on 08/27/07. For personal use only. IMMUNOLOGIC TOLERANCE 45 rabbit antibody in the conjugate, the end result was an enhancedresponse, suggesting that the conjoint action of (normally toleragenic) conjugate and active T cell help was immunogenic. Whenribonuclease was linked to antibody in this fashion, this normally poor immunogeninduced priming or immunologicmemory,but this immunogenicitywas lost if recipient mice had been previously madetolerant to the rabbit IgG carrier.
Stone, Chief, Extramural Programs, National Institute of Neurological Diseases and Blindness, dated December 14, 1953, which read, DearDr. Kabat: Your application for a research grant, identified as B-9(C4), and entitled "Immunochemical Studies on Acute Disseminated Encephalomyelitis and on Multiple Sclerosis" has nowhad a final review. I regret to report that this request falls in the group of applications for which grants cannot be made. This was followed by a visit to Houston Merritt saying that this was because of the political climate, that they didn’t knowexactly why,etc.
Annual Review of Immunology Volume 1 1983 by William E. Paul